Pharmaceutical and biomaterial engineering via electrohydrodynamic atomization technologies.

نویسندگان

  • Prina Mehta
  • Rita Haj-Ahmad
  • Manoochehr Rasekh
  • Muhammad S Arshad
  • Ashleigh Smith
  • Susanna M van der Merwe
  • Xiang Li
  • Ming-Wei Chang
  • Zeeshan Ahmad
چکیده

Complex micro- and nano-structures enable crucial developments in the healthcare remit (e.g., pharmaceutical and biomaterial sciences). In recent times, several technologies have been developed and explored to address key healthcare challenges (e.g., advanced chemotherapy, biomedical diagnostics and tissue regeneration). Electrohydrodynamic atomization (EHDA) technologies are rapidly emerging as promising candidates to address these issues. The fundamental principle driving EHDA engineering relates to the action of an electric force (field) on flowing conducting medium (formulation) giving rise to a stable Taylor cone. Through careful optimization of process parameters, material properties and selection, nozzle and needle design, and collection substrate method, complex active micro- and nano-structures are engineered. This short review focuses on key selected recent and established advances in the field of pharmaceutical and biomaterial applications.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Controlled Morphing of Microbubbles to Beaded Nanofibers via Electrically Forced Thin Film Stretching

Topography and microstructure engineering are rapidly evolving areas of importance for biomedical and pharmaceutical remits. Here, PVA (Polyvinyl alcohol) microbubbles (diameter range ~126 to 414 μm) were used to fabricate beaded (beads-on) nanofibers using an electrohydrodynamic atomization (EHDA) technique. Mean fiber diameter, inter-bead distance, and aspect ratio (AR) were investigated by r...

متن کامل

Electrohydrodynamic atomization: a versatile process for preparing materials for biomedical applications.

Electrohydrodynamic atomization phenomena have increasingly attracted the attention of researchers who are interested in building micro- or nanometer architectures, such as fibers and encapsulated particles with a controllable microstructure. There are two main electrohydrodynamic atomization techniques: electrospraying and electrospinning. These techniques are unique processes in that they pro...

متن کامل

Synthesis and Characterization of Hydroxyapatite Nanocrystals via Chemical Precipitation Technique

     In this study, hydroxyapatite (HA) nanocrystals have been synthesized via chemical precipitation technique. Diammonium hydrogen phosphate and calcium nitrate 4-hydrate were used as starting materials and sodium hydroxide solution was used as the agent for pH adjustment. The powder sample was evaluated by techniques such as scanning electron microscope, transmission electron microscope, Fou...

متن کامل

Droplet and Particle Formation in the Electrohydrodynamic Atomization Process

1 MEBCS Program, Singapore-MIT Alliance, 4 Engineering Drive 3, 117576, Singapore, Singapore 2 Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117576, Singapore 3 Institute of High Performance Computing, 1 Science Park Road #01-01 The Capricorn, Singapore Science Park II, Singapore 117528 4 National University of Singapore...

متن کامل

Core/shell microencapsulation of indomethacin/paracetamol by co-axial electrohydrodynamic atomization

• Oral drug delivery systems were prepared by single step co-axial electrohydrodynamic atomization with high processing yield. • Polymer carrier systems (PCS) suitable for the process and drugs were developed first. • Model drugs of different aqueous solubility were successfully incorporated in the PCS with 50-70% encapsulation efficiency. • This technique is a versatile platform for combined d...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Drug discovery today

دوره 22 1  شماره 

صفحات  -

تاریخ انتشار 2017